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Author (up) Fernandez, F.; Lu, D.; Ha, P.; Costacurta, P.; Chavez, R.; Heller, H.C.; Ruby, N.F. url  doi
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  Title Circadian rhythm. Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing Type Journal Article
  Year 2014 Publication Science (New York, N.Y.) Abbreviated Journal Science  
  Volume 346 Issue 6211 Pages 854-857  
  Keywords Animals; circadian rhythm; circadian disruption; memory; suprachiasmatic nucleus; Biological Clocks; dysrhythmia; Siberian hamster; Phodopus sungorus; sleep  
  Abstract Chronic circadian dysfunction impairs declarative memory in humans but has little effect in common rodent models of arrhythmia caused by clock gene knockouts or surgical ablation of the suprachiasmatic nucleus (SCN). An important problem overlooked in these translational models is that human dysrhythmia occurs while SCN circuitry is genetically and neurologically intact. Siberian hamsters (Phodopus sungorus) are particularly well suited for translational studies because they can be made arrhythmic by a one-time photic treatment that severely impairs spatial and recognition memory. We found that once animals are made arrhythmic, subsequent SCN ablation completely rescues memory processing. These data suggest that the inhibitory effects of a malfunctioning SCN on cognition require preservation of circuitry between the SCN and downstream targets that are lost when these connections are severed.  
  Address Biology Department, Stanford University, Stanford CA, USA. ruby@stanford.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0036-8075 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25395537 Approved no  
  Call Number IDA @ john @ Serial 1069  
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