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Author (up) Van Dycke, K.C.G.; Rodenburg, W.; van Oostrom, C.T.M.; van Kerkhof, L.W.M.; Pennings, J.L.A.; Roenneberg, T.; van Steeg, H.; van der Horst, G.T.J. url  doi
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  Title Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice Type Journal Article
  Year 2015 Publication Current Biology : CB Abbreviated Journal Curr Biol  
  Volume 25 Issue 14 Pages 1932-1937  
  Keywords Animals  
  Abstract Although epidemiological studies in shift workers and flight attendants have associated chronic circadian rhythm disturbance (CRD) with increased breast cancer risk, causal evidence for this association is lacking [1, 2]. Several scenarios have been proposed to contribute to the shift work-cancer connection: (1) internal desynchronization, (2) light at night (resulting in melatonin suppression), (3) sleep disruption, (4) lifestyle disturbances, and (5) decreased vitamin D levels due to lack of sunlight [3]. The confounders inherent in human field studies are less problematic in animal studies, which are therefore a good approach to assess the causal relation between circadian disturbance and cancer. However, the experimental conditions of many of these animal studies were far from the reality of human shift workers. For example, some involved xenografts (addressing tumor growth rather than cancer initiation and/or progression) [4, 5], chemically induced tumor models [6, 7], or continuous bright light exposure, which can lead to suppression of circadian rhythmicity [8, 9]. Here, we have exposed breast cancer-prone p53(R270H(c)/+)WAPCre conditional mutant mice (in a FVB genetic background) to chronic CRD by subjecting them to a weekly alternating light-dark (LD) cycle throughout their life. Animals exposed to the weekly LD inversions showed a decrease in tumor suppression. In addition, these animals showed an increase in body weight. Importantly, this study provides the first experimental proof that CRD increases breast cancer development. Finally, our data suggest internal desynchronization and sleep disturbance as mechanisms linking shift work with cancer development and obesity.  
  Address Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands. Electronic address: g.vanderhorst@erasmusmc.nl  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0960-9822 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26196479 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1221  
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