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Author Oike, H.; Sakurai, M.; Ippoushi, K.; Kobori, M. url  doi
  Title Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work Type Journal Article
  Year 2015 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume 465 Issue 3 Pages 556-561  
  Keywords Animals; *Circadian Clocks; *Disease Models, Animal; *Feeding Behavior; Jet Lag Syndrome/*physiopathology; Male; Mice; Mice, Inbred C57BL; Obesity/etiology/*physiopathology/*prevention & control; Photoperiod; Circadian rhythm; Clock genes; Jet lag; Metabolic disorders; Obesity; Shift work  
  Abstract Recent findings have uncovered intimate relationships between circadian clocks and energy metabolism. Epidemiological studies have shown that the frequency of obesity and metabolic disorders increases among shift-workers. Here we found that a chronic shift in light/dark (LD) cycles comprising an advance of six hours twice weekly, induced obesity in mice. Under such conditions that imitate jet lag/shift work, body weight and glucose intolerance increased, more fat accumulated in white adipose tissues and the expression profiles of metabolic genes changed in the liver compared with normal LD conditions. Mice fed at a fixed 12 h under the LD shift notably did not develop symptoms of obesity despite isocaloric intake. These results suggest that jet lag/shift work induces obesity as a result of fluctuating feeding times and it can be prevented by fixing meal times. This rodent model of obesity might serve as a useful tool for understanding why shift work induces metabolic disorders.  
  Address Food Function Division, National Food Research Institute, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan; oike(at)  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume (down) Series Issue Edition  
  ISSN 0006-291X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26297949 Approved no  
  Call Number IDA @ john @ Serial 1318  
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