||The Suomi National Polar-orbiting (NPP) Visible Infrared Imaging Radiometer Suite (VIIRS) Day-Night Band (DNB) measures visible and near-infrared light extending over seven orders of magnitude of dynamic range. This makes radiometric calibration difficult. We have observed that DNB imagery has striping, banding and other nonuniformitiesâday or night. We identified the causes as stray light, nonlinearity, detector crosstalk, hysteresis and mirror-side variation. We found that these affect both Earth-view and calibration signals. These present an obstacle to interpretation by users of DNB products. Because of the nonlinearity we chose the histogram matching destriping technique which we found is successful for daytime, twilight and nighttime scenes. Because of the very large dynamic range of the DNB, we needed to add special processes to the histogram matching to destripe all scenes, especially imagery in the twilight regions where scene illumination changes rapidly over short distances. We show that destriping aids image analysts, and makes it possible for advanced automated cloud typing algorithms. Manual or automatic identification of other features, including polar ice and gravity waves in the upper atmosphere are also discussed. In consideration of the large volume of data produced 24 h a day by the VIIRS DNB, we present methods for reducing processing time.