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Author (up) Buijs, F.N.; Leon-Mercado, L.; Guzman-Ruiz, M.; Guerrero-Vargas, N.N.; Romo-Nava, F.; Buijs, R.M. url  doi
  Title The Circadian System: A Regulatory Feedback Network of Periphery and Brain Type Journal Article
  Year 2016 Publication Physiology (Bethesda, Md.) Abbreviated Journal Physiology (Bethesda)  
  Volume 31 Issue 3 Pages 170-181  
  Keywords Human health; circadian rhythm; suprachiasmatic nucleus; brain; clock genes; SCN; review; circadian desynchronization; shiftwork  
  Abstract Circadian rhythms are generated by the autonomous circadian clock, the suprachiasmatic nucleus (SCN), and clock genes that are present in all tissues. The SCN times these peripheral clocks, as well as behavioral and physiological processes. Recent studies show that frequent violations of conditions set by our biological clock, such as shift work, jet lag, sleep deprivation, or simply eating at the wrong time of the day, may have deleterious effects on health. This infringement, also known as circadian desynchronization, is associated with chronic diseases like diabetes, hypertension, cancer, and psychiatric disorders. In this review, we will evaluate evidence that these diseases stem from the need of the SCN for peripheral feedback to fine-tune its output and adjust physiological processes to the requirements of the moment. This feedback can vary from neuronal or hormonal signals from the liver to changes in blood pressure. Desynchronization renders the circadian network dysfunctional, resulting in a breakdown of many functions driven by the SCN, disrupting core clock rhythms in the periphery and disorganizing cellular processes that are normally driven by the synchrony between behavior and peripheral signals with neuronal and humoral output of the hypothalamus. Consequently, we propose that the loss of synchrony between the different elements of this circadian network as may occur during shiftwork and jet lag is the reason for the occurrence of health problems.  
  Address Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico; ruudbuijs(at)  
  Corporate Author Thesis  
  Publisher American Physiological Society Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1548-9221 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27053731 Approved no  
  Call Number IDA @ john @ Serial 1429  
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