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Author  |
Sahar, S.; Sassone-Corsi, P. |
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Title |
Regulation of metabolism: the circadian clock dictates the time |
Type |
Journal Article |
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Year |
2012 |
Publication |
Trends in Endocrinology and Metabolism: TEM |
Abbreviated Journal |
Trends Endocrinol Metab |
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Volume |
23 |
Issue |
1 |
Pages |
1-8 |
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Keywords |
Animals; Chronobiology Disorders/metabolism; *Circadian Clocks; *Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins/metabolism; *Energy Metabolism; Humans; Metabolome |
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Abstract |
Circadian rhythms occur with a periodicity of approximately 24h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders. |
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Address |
Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA 92697, USA |
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Language |
English |
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Original Title |
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Series Title |
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Series Volume |
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Edition |
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ISSN |
1043-2760 |
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Notes |
PMID:22169754; PMCID:PMC3259741 |
Approved |
no |
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Call Number |
IDA @ john @ |
Serial |
151 |
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