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Author Bonmati-Carrion, M.A.; Hild, K.; Isherwood, C.; Sweeney, S.J.; Revell, V.L.; Skene, D.J.; Rol, M.A.; Madrid, J.A.
Title Relationship between Human Pupillary Light Reflex and Circadian System Status Type Journal Article
Year 2016 Publication PloS one Abbreviated Journal PLoS One
Volume 11 Issue 9 Pages e0162476
Keywords Human Health
Abstract Intrinsically photosensitive retinal ganglion cells (ipRGCs), whose photopigment melanopsin has a peak of sensitivity in the short wavelength range of the spectrum, constitute a common light input pathway to the olivary pretectal nucleus (OPN), the pupillary light reflex (PLR) regulatory centre, and to the suprachiasmatic nuclei (SCN), the major pacemaker of the circadian system. Thus, evaluating PLR under short wavelength light (lambdamax </= 500 nm) and creating an integrated PLR parameter, as a possible tool to indirectly assess the status of the circadian system, becomes of interest. Nine monochromatic, photon-matched light stimuli (300 s), in 10 nm increments from lambdamax 420 to 500 nm were administered to 15 healthy young participants (8 females), analyzing: i) the PLR; ii) wrist temperature (WT) and motor activity rhythms (WA), iii) light exposure (L) pattern and iv) diurnal preference (Horne-Ostberg), sleep quality (Pittsburgh) and daytime sleepiness (Epworth). Linear correlations between the different PLR parameters and circadian status index obtained from WT, WA and L recordings and scores from questionnaires were calculated. In summary, we found markers of robust circadian rhythms, namely high stability, reduced fragmentation, high amplitude, phase advance and low internal desynchronization, were correlated with a reduced PLR to 460-490 nm wavelengths. Integrated circadian (CSI) and PLR (cp-PLR) parameters are proposed, that also showed an inverse correlation. These results demonstrate, for the first time, the existence of a close relationship between the circadian system robustness and the pupillary reflex response, two non-visual functions primarily under melanopsin-ipRGC input.
Address Chronobiology Laboratory, Department of Physiology, Faculty of Biology, University of Murcia, IMIB-Arrixaca, 30100, Espinardo, Murcia, Spain
Corporate Author (up) Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1932-6203 ISBN Medium
Area Expedition Conference
Notes PMID:27636197; PMCID:PMC5026360 Approved no
Call Number LoNNe @ kyba @ Serial 1537
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