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Author Kloog, I.; Haim, A.; Stevens, R.G.; Portnov, B.A. url  doi
  Title Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men Type Journal Article
  Year (down) 2009 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume 26 Issue 1 Pages 108-125  
  Keywords Circadian Rhythm; Colonic Neoplasms/*epidemiology; Electricity; Humans; Incidence; *Light; Lung Neoplasms/*epidemiology; Male; Prostatic Neoplasms/*epidemiology; Risk Factors; Urban Population; World Health; Oncogenesis  
  Abstract The incidence rates of cancers in men differ by countries of the world. We compared the incidence rates of three of the most common cancers (prostate, lung, and colon) in men residing in 164 different countries with the population-weighted light at night (LAN) exposure and with several developmental and environmental indicators, including per capita income, percent urban population, and electricity consumption. The estimate of per capita LAN exposure was a novel aspect of this study. Both ordinary least squares (OLS) and spatial error (SE) regression models were used in the analysis. We found a significant positive association between population exposure to LAN and incidence rates of prostate cancer, but no such association with lung cancer or colon cancer. The prostate cancer result is consistent with a biological theory and a limited number of previous studies of circadian disruption and risk. The LAN-prostate cancer connection is postulated to be due to suppression of melatonin and/or disruption of clock gene function. An analysis holding other variables at average values across the 164 countries yielded a risk of prostate cancer in the highest LAN-exposed countries 110% higher than in the lowest LAN exposed countries. This observed association is a necessary condition for a potentially large effect of LAN on risk of prostate cancer. However, it is not sufficient due to potential confounding by factors that increase the risk of prostate cancer and are also associated with LAN among the studied countries.  
  Address Department of Natural Resources & Environmental Management, Faculty of Social Sciences, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19142761 Approved no  
  Call Number IDA @ john @ Serial 163  
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