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Author (up) Fonken, L.K.; Weil, Z.M.; Nelson, R.J. url  doi
  Title Dark nights reverse metabolic disruption caused by dim light at night Type Journal Article
  Year 2013 Publication Obesity (Silver Spring, Md.) Abbreviated Journal Obesity (Silver Spring)  
  Volume 21 Issue 6 Pages 1159-1164  
  Keywords Animals; Body Mass Index; Energy Intake; Gene Expression; Glucose Tolerance Test; *Light; Male; Mice; Obesity/*epidemiology/etiology; *Photoperiod; Weight Gain  
  Abstract OBJECTIVE: The increasing prevalence of obesity and related metabolic disorders coincides with increasing exposure to light at night. Previous studies report that mice exposed to dim light at night (dLAN) develop symptoms of metabolic syndrome. This study investigated whether mice returned to dark nights after dLAN exposure recover metabolic function. DESIGN AND METHODS: Male Swiss-Webster mice were assigned to either: standard light-dark (LD) conditions for 8 weeks (LD/LD), dLAN for 8 weeks (dLAN/dLAN), LD for 4 weeks followed by 4 weeks of dLAN (LD/dLAN), and dLAN for 4 weeks followed by 4 weeks of LD (dLAN/LD). RESULTS: After 4 weeks in their respective lighting conditions both groups initially placed in dLAN increased body mass gain compared to LD mice. Half of the dLAN mice (dLAN/LD) were then transferred to LD and vice versa (LD/dLAN). Following the transfer dLAN/dLAN and LD/dLAN mice gained more weight than LD/LD and dLAN/LD mice. At the conclusion of the study dLAN/LD mice did not differ from LD/LD mice with respect to weight gain and had lower fat pad mass compared to dLAN/dLAN mice. Compared to all other groups dLAN/dLAN mice decreased glucose tolerance as indicated by an intraperitoneal glucose tolerance test at week 7, indicating that dLAN/LD mice recovered glucose metabolism. dLAN/dLAN mice also increased MAC1 mRNA expression in peripheral fat as compared to both LD/LD and dLAN/LD mice, suggesting peripheral inflammation is induced by dLAN, but not sustained after return to LD. CONCLUSION: These results suggest that re-exposure to dark nights ameliorates metabolic disruption caused by dLAN exposure.  
  Address Department of Neuroscience and Institute for Behavioral Medicine Research, Wexner Medical Center, Ohio State University, Columbus, Ohio 43210, USA.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1930-7381 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23666854 Approved no  
  Call Number IDA @ john @ Serial 167  
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