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Author (up) Yoshinaka, K.; Yamaguchi, A.; Matsumura, R.; Node, K.; Tokuda, I.; Akashi, M. url  doi
  Title Effect of different light-dark schedules on estrous cycle in mice, and implications for mitigating the adverse impact of night work Type Journal Article
  Year 2017 Publication Genes to Cells : Devoted to Molecular & Cellular Mechanisms Abbreviated Journal Genes Cells  
  Volume 22 Issue 10 Pages 876-884  
  Keywords Animals  
  Abstract Approximately 20% of workers in developed countries are involved in night work. Nevertheless, many studies have strongly suggested that night-work-induced chronic circadian misalignment increases the risk of a diverse range of health problems. Although a relation between night work and irregular menstrual cycles has been indicated epidemiologically, a direct causal link remains elusive. Here, we report that repetitive reversal of light-dark (LD) cycles triggers irregular estrous cycles in mice. The findings showed that the estrous cycle remained irregular for more than four weeks after the mice were returned to regular LD cycles. Importantly, the magnitude of the negative impact of reversed LD cycles on the estrous cycle, or more specifically the decreased number of normal estrous cycles during the observation period, was dependent on the difference in the frequency of LD reversal. Presently, no clear solution to prevent night-work-mediated menstrual abnormalities is available, and reducing night work in modern society is difficult. Our findings indicate that optimizing work schedules could significantly prevent menstrual problems without reducing total night-work time.  
  Address The Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1356-9597 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28884885 Approved no  
  Call Number LoNNe @ kyba @ Serial 1722  
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