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Author (up) Boswell, W.T.; Boswell, M.; Walter, D.J.; Navarro, K.L.; Chang, J.; Lu, Y.; Savage, M.G.; Shen, J.; Walter, R.B. url  doi
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  Title Exposure to 4100K fluorescent light elicits sex specific transcriptional responses in Xiphophorus maculatus skin Type Journal Article
  Year 2018 Publication Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP Abbreviated Journal Comp Biochem Physiol C Toxicol Pharmacol  
  Volume 208 Issue Pages 96-104  
  Keywords Animals  
  Abstract It has been reported that exposure to artificial light may affect oxygen intake, heart rate, absorption of vitamins and minerals, and behavioral responses in humans. We have reported specific gene expression responses in the skin of Xiphophorus fish after exposure to ultraviolet light (UV), as well as, both broad spectrum and narrow waveband visible light. In regard to fluorescent light (FL), we have shown that male X. maculatus exposed to 4100K FL (i.e. “cool white”) rapidly suppress transcription of many genes involved with DNA replication and repair, chromosomal segregation, and cell cycle progression in skin. We have also detailed sex specific transcriptional responses of Xiphophorus skin after exposure to UVB. However, investigation of gender differences in global gene expression response after exposure to 4100K FL has not been reported, despite common use of this FL source for residential, commercial, and animal facility illumination. Here, we compare RNASeq results analyzed to assess changes in the global transcription profiles of female and male X. maculatus skin in response to 4100K FL exposure. Our results suggest 4100K FL exposure incites a sex-biased genetic response including up-modulation of inflammation in females and down modulation of DNA repair/replication in males. In addition, we identify clusters of genes that become oppositely modulated in males and females after FL exposure that are principally involved in cell death and cell proliferation.  
  Address Department of Chemistry and Biochemistry, Xiphophorus Genetic Stock Center, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. Electronic address: RW12@txstate.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1532-0456 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28965926 Approved no  
  Call Number LoNNe @ kyba @ Serial 1739  
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