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Author (up) Borck, P.C.; Batista, T.M.; Vettorazzi, J.F.; Soares, G.M.; Lubaczeuski, C.; Guan, D.; Boschero, A.C.; Vieira, E.; Lazar, M.A.; Carneiro, E.M. url  doi
  Title Nighttime light exposure enhances Rev-erbalpha-targeting microRNAs and contributes to hepatic steatosis Type Journal Article
  Year 2018 Publication Metabolism: Clinical and Experimental Abbreviated Journal Metabolism  
  Volume 85 Issue Pages 250-258  
  Keywords Animals  
  Abstract OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbalpha and up-regulation of its lipogenic targets ACL and FAS in liver. Furthermore, the expression of Rev-erbalpha-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group. Consistently, overexpression of these miRNAs in primary hepatocytes reduced Rev-erbalpha expression at the mRNA and protein levels. Importantly, overexpression of Rev-erbalpha-targeting miRNAs increased mRNA levels of Acly and Fasn. CONCLUSION: Thus, altered miRNA profile is an important mechanism underlying the disruption of the peripheral clock caused by exposure to ALAN, which could lead to hepatic steatosis.  
  Address Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil; Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0026-0495 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29751019 Approved no  
  Call Number GFZ @ kyba @ Serial 1891  
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