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Author (up) Nelson, R.J.; Chbeir, S. url  doi
openurl 
  Title Dark matters: effects of light at night on metabolism Type Journal Article
  Year 2018 Publication The Proceedings of the Nutrition Society Abbreviated Journal Proc Nutr Soc  
  Volume 77 Issue 3 Pages 223-229  
  Keywords Human Health  
  Abstract Life on earth has evolved during the past several billion years under relatively bright days and dark night conditions. The wide-spread adoption of electric lights during the past century exposed animals, both human and non-human, to significant light at night for the first time in their evolutionary history. Endogenous circadian clocks depend on light to entrain to the external daily environment and seasonal rhythms depend on clear nightly melatonin signals to assess time of year. Thus, light at night can derange temporal adaptations. Indeed, disruption of naturally evolved light-dark cycles results in several physiological and behavioural changes with potentially serious implications for physiology, behaviour and mood. In this review, data from night-shift workers on their elevated risk for metabolic disorders, as well as data from animal studies will be discussed. Night-shift workers are predisposed to obesity and dysregulated metabolism that may result from disrupted circadian rhythms. Although studies in human subjects are correlative, animal studies have revealed several mechanisms through which light at night may exert its effects on metabolism by disrupting circadian rhythms that are associated with inflammation, both in the brain and in the periphery. Disruption of the typical timing of food intake is a key effect of light at night and subsequent metabolic dysregulation. Strategies to avoid the effects of light at night on body mass dysregulation should be pursued.  
  Address Department of Neuroscience,The Ohio State University,Columbus, OH 43210,USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0029-6651 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29747703 Approved no  
  Call Number GFZ @ kyba @ Serial 1896  
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