||Vision neuroscience research and vision lighting research have historically run on parallel paths. The former discipline is primarily interested in understanding the basic neurophysiological and biophysical characteristics of the visual system, while the latter is primarily interested in understanding the best means for designing and engineering perceptions of architectural spaces and for improving safety and productivity of indoor and outdoor applications. This review frames vision lighting research conducted over the past century in terms of current vision neuroscience research, illustrating the similarities in the two research paths. It is also argued that visual lighting research could be more impactful on society at large if the basic framework established by vision neuroscience were considered in planning and conducting applications research. Specifically, studies aimed at understanding the luminous environment in terms of the what and the where of visual subsystems would provide the foundation for developing unique and highly valuable lighting applications and standards.