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Author  |
Masri, S.; Sassone-Corsi, P. |
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Title |
The emerging link between cancer, metabolism, and circadian rhythms |
Type |
Journal Article |
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Year |
2018 |
Publication |
Nature Medicine |
Abbreviated Journal |
Nat Med |
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Volume |
24 |
Issue |
12 |
Pages |
1795-1803 |
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Keywords |
Human Health; Review |
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Abstract |
The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies. |
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Address |
Department of Biological Chemistry, Center for Epigenetics and Metabolism, INSERM U1233, University of California Irvine, Irvine, CA, USA. psc@uci.edu |
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Language |
English |
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ISSN |
1078-8956 |
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Notes |
PMID:30523327 |
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no |
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Call Number |
GFZ @ kyba @ |
Serial |
2135 |
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