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Author (up) Rahman, S.A.; Bibbo, C.; Olcese, J.; Czeisler, C.A.; Robinson, J.N.; Klerman, E.B. url  doi
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  Title Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy Type Journal Article
  Year 2019 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res  
  Volume in press Issue Pages  
  Keywords Human Health  
  Abstract In humans, circulating levels of the hormone melatonin and the initiation of spontaneous labor are both higher at night than during the day. Since activation of uterine melatonin receptors can stimulate human in vitro uterine contractions and these receptors are only expressed on the uterine tissue of women in labor, we hypothesized that circulating melatonin concentrations would affect uterine contractions in vivo. We evaluated the impact of light-induced modulation of melatonin secretion on uterine contractions in women during late third-trimester (~36-39 weeks) of pregnancy in two inpatient protocols. We found a significant (p<0.05) positive linear association between circulating melatonin concentrations and the number of uterine contractions under both protocols. On average, uterine contractions increased between 1.4 to 2.1 contractions per 30 minutes for every 10 pg/ml*h increase in melatonin concentration. These findings have both basic science and clinical implications for pregnant women, since endogenous melatonin levels and melatonin receptor activity can be altered by light and/or pharmaceutical agents. This article is protected by copyright. All rights reserved.  
  Address Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-3098 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30739346 Approved no  
  Call Number GFZ @ kyba @ Serial 2203  
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