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Author  |
Rahman, S.A.; Bibbo, C.; Olcese, J.; Czeisler, C.A.; Robinson, J.N.; Klerman, E.B. |
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Title |
Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy |
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Journal Article |
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Year |
2019 |
Publication |
Journal of Pineal Research |
Abbreviated Journal |
J Pineal Res |
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in press |
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Keywords |
Human Health |
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Abstract |
In humans, circulating levels of the hormone melatonin and the initiation of spontaneous labor are both higher at night than during the day. Since activation of uterine melatonin receptors can stimulate human in vitro uterine contractions and these receptors are only expressed on the uterine tissue of women in labor, we hypothesized that circulating melatonin concentrations would affect uterine contractions in vivo. We evaluated the impact of light-induced modulation of melatonin secretion on uterine contractions in women during late third-trimester (~36-39 weeks) of pregnancy in two inpatient protocols. We found a significant (p<0.05) positive linear association between circulating melatonin concentrations and the number of uterine contractions under both protocols. On average, uterine contractions increased between 1.4 to 2.1 contractions per 30 minutes for every 10 pg/ml*h increase in melatonin concentration. These findings have both basic science and clinical implications for pregnant women, since endogenous melatonin levels and melatonin receptor activity can be altered by light and/or pharmaceutical agents. This article is protected by copyright. All rights reserved. |
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Address |
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA |
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Language |
English |
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ISSN |
0742-3098 |
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Notes |
PMID:30739346 |
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no |
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Call Number |
GFZ @ kyba @ |
Serial |
2203 |
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