||This paper describes a methodology to assess the evidence of human presence and humanactivities in the Brazilian Amazonia region using DMSP/OLS night-time satellite sensorimagery. It consists on exploring the potential of the sensor data for regional studies analysingthe correlation between DMSP night-time light foci and population, and the correlation be-tween DMSP night-time light foci and electrical power consumption. In the mosaic of DMSP/OLS night-time light imagery from September 1999, 248 towns were detected from a total of749municıpiosin Amazonia. It was found that the night-time light foci were related to human presence in the region, including urban settlements, mining, industries, and civil construction,observed in ancillary Landsat TM and JERS imagery data. The analysis considering only thestate of Para revealed a linear relation (R2¼0:79) between urban population from the 1996census data and DMSP night-time light foci. Similarly, electrical power consumption for 1999was linearly correlated with DMSP night-time light foci. Thus the DMSP/OLS imagery can beused as an indicator of human presence in the analysis of spatial–temporal patterns in theAmazonia region. These results are very useful considering the continental dimension ofAmazonia, the absence of demographic information between the official population census(every 10 years), and the dynamics and complexity of human activities in the region. ThereforeDMSP night-time light foci are a valuable data source for global studies, modelling, and planning activities when the human dimension must be considered throughout Amazonia.