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Author (up) Li, Y.; Cheng, S.; Li, L.; Zhao, Y.; Shen, W.; Sun, X. url  doi
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  Title Light-exposure at night impairs mouse ovary development via cell apoptosis and DNA damage Type Journal Article
  Year 2019 Publication Bioscience Reports Abbreviated Journal Biosci Rep  
  Volume Issue Pages  
  Keywords Animals  
  Abstract The alternation of light and dark rhythm causes a series of physiological, biochemical and metabolic changes in animals, which also alters the growth and development of animals, and feeding, migration, reproduction and other behavioral activities. In recent years, many studies have reported the effects of long-term (more than 6 weeks) illumination on ovarian growth and development. In this study, we observed the damage, repair and apoptosis of ovarian DNA in a short period of illumination. The results showed that, in short time (less than 2 weeks) illumination conditions, the 24 hrs-light treatment caused the reduction of total ovarian follicle number and downregulation of circadian clock related genes. Furthermore, the changed levels of serum sex hormones were also detected after 24 hrs-light exposure, of which the concentrations of LH (luteinizing hormone), FSH (follicle-stimulating hormone) and E2 (estradiol) were increased, but the concentration of PROG (progesterone) was decreased. Moreover, 24 hrs-light exposure increased the expression of DNA damage and repair related genes, the number of TUNEL and RAD51 positive cells. These results indicated that 24 hrs-light exposure for 4 days, 8days and 12 days increased DNA damage and cell apoptosis, thereby affecting the development of ovary.  
  Address Qingdao agricultural university, Qingdao, China xfsun@qau.edu.cn  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0144-8463 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30962269 Approved no  
  Call Number GFZ @ kyba @ Serial 2293  
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