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Author (up) Hatori, M.; Gronfier, C.; Van Gelder, R.N.; Bernstein, P.S.; Carreras, J.; Panda, S.; Marks, F.; Sliney, D.; Hunt, C.E.; Hirota, T.; Furukawa, T.; Tsubota, K. url  doi
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  Title Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies Type Journal Article
  Year 2017 Publication NPJ Aging and Mechanisms of Disease Abbreviated Journal NPJ Aging Mech Dis  
  Volume 3 Issue Pages 9  
  Keywords Commentary; Human Health  
  Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin. Melanopsin-expressing cells constitute 1-2% of retinal ganglion cells in the adult mammalian retina, are intrinsically photosensitive, and integrate photic information from rods and cones to control nonimage-forming adaptation. Action spectra of ipRGCs and of melanopsin photopigment peak around 480 nm blue light. Understanding melanopsin function lets us recognize considerable physiological effects of blue light, which is increasingly important in our modern society that uses light-emitting diode. Misalignment of circadian rhythmicity is observed in numerous conditions, including aging, and is thought to be involved in the development of age-related disorders, such as depression, diabetes, hypertension, obesity, and cancer. The appropriate regulation of circadian rhythmicity by proper lighting is therefore essential. This perspective introduces the potential risks of excessive blue light for human health through circadian rhythm disruption and sleep deprivation. Knowing the positive and negative aspects, this study claims the importance of being exposed to light at optimal times and intensities during the day, based on the concept of the circadian clock, ultimately to improve quality of life to have a healthy and longer life.  
  Address Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo Japan.0000 0004 1936 9959grid.26091.3c  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2056-3973 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28649427; PMCID:PMC5473809 Approved no  
  Call Number GFZ @ kyba @ Serial 2462  
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