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Author (up) Bullock, B.; McGlashan, E.M.; Burns, A.C.; Lu, B.S.; Cain, S.W. url  doi
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  Title Traits related to bipolar disorder are associated with an increased post-illumination pupil response Type Journal Article
  Year 2019 Publication Psychiatry Research Abbreviated Journal Psychiatry Res  
  Volume 278 Issue Pages 35-41  
  Keywords Human Health  
  Abstract Mood states in bipolar disorder appear to be closely linked to changes in sleep and circadian function. It has been suggested that hypersensitivity of the circadian system to light may be a trait vulnerability for bipolar disorder. Healthy persons with emotional-behavioural traits associated with bipolar disorder also appear to exhibit problems with circadian rhythms, which may be associated with individual differences in light sensitivity. This study investigated the melanopsin-driven post-illumination pupil response (PIPR) in relation to emotional-behavioural traits associated with bipolar disorder (measured with the General Behavior Inventory) in a non-clinical group (n=61). An increased PIPR was associated with increased bipolar disorder-related traits. Specifically, the hypomania scale of the General Behavior Inventory was associated with an increased post-blue PIPR. Further, both the full hypomania and shortened '7 Up' scales were significantly predicted by PIPR, after age, sex and depressive traits were controlled. These findings suggest that increased sensitivity to light may be a risk factor for mood problems in the general population, and support the idea that hypersensitivity to light is a trait vulnerability for, rather than symptom of, bipolar disorder.  
  Address School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia. Electronic address: sean.cain@monash.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0165-1781 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31136914 Approved no  
  Call Number GFZ @ kyba @ Serial 2510  
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