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Author (up) Opperhuizen, A.-L.; Foppen, E.; Jonker, M.; Wackers, P.; van Faassen, M.; van Weeghel, M.; van Kerkhof, L.; Fliers, E.; Kalsbeek, A. url  doi
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  Title Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System Type Journal Article
  Year 2019 Publication Frontiers in Neuroscience Abbreviated Journal Front. Neurosci.  
  Volume 13 Issue Pages  
  Keywords Animals  
  Abstract Exposure to light at night (LAN) has been associated with serious pathologies, including obesity, diabetes and cancer. Recently we showed that 2 h of LAN impaired glucose tolerance in rats. Several studies have suggested that the autonomic nervous system (ANS) plays an important role in communicating these acute effects of LAN to the periphery. Here, we investigated the acute effects of LAN on the liver transcriptome of male Wistar rats. Expression levels of individual genes were not markedly affected by LAN, nevertheless pathway analysis revealed clustered changes in a number of endocrine pathways. Subsequently, we used selective hepatic denervations [sympathetic (Sx), parasympathetic (Px), total (Tx, i.e., Sx plus Px), sham] to investigate the involvement of the ANS in the effects observed. Surgical removal of the sympathetic or parasympathetic hepatic branches of the ANS resulted in many, but small changes in the liver transcriptome, including a pathway involved with circadian clock regulation, but it clearly separated the four denervation groups. On the other hand, analysis of the liver metabolome was not able to separate the denervation groups, and only 6 out of 78 metabolites were significantly up- or downregulated after denervations. Finally, removal of the sympathetic and parasympathetic hepatic nerves combined with LAN exposure clearly modulated the effects of LAN on the liver transcriptome, but left most endocrine pathways unaffected.  
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  ISSN 1662-453X ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ intern @ Serial 2539  
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