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Author  |
Rumanova, V.S.; Okuliarova, M.; Molcan, L.; Sutovska, H.; Zeman, M. |
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Title |
Consequences of low-intensity light at night on cardiovascular and metabolic parameters in spontaneously hypertensive rats |
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Journal Article |
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Year |
2019 |
Publication |
Canadian Journal of Physiology and Pharmacology |
Abbreviated Journal |
Can J Physiol Pharmacol |
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Volume |
97 |
Issue |
9 |
Pages |
863-871 |
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Keywords |
Animals; mouse models |
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Abstract |
Circadian rhythms are an inherent property of physiological processes and can be disturbed by irregular environmental cycles, including artificial light at night (ALAN). Circadian disruption may contribute to many pathologies, such as hypertension, obesity and type 2 diabetes, but the underlying mechanisms are not understood. Our study investigated the consequences of ALAN on cardiovascular and metabolic parameters in spontaneously hypertensive rats (SHR), which represent an animal model of essential hypertension and insulin resistance. Adult males were exposed to a light (L)/dark (D) cycle of 12:12 h and the ALAN group experienced dim light at night (1-2 lux), either for 2 or 5 weeks. Rats on ALAN showed a loss of LD variability for systolic blood pressure (SysBP), but not for heart rate. Moreover, a gradual increase of SysBP was recorded over 5 weeks of ALAN. Exposure to ALAN increased plasma insulin and hepatic triglyceride levels. An increased expression of metabolic transcription factors, Pparalpha and Ppar, in the epididymal fat and a decreased expression of Glut4 in the heart was found in the ALAN group. Our results demonstrate that low-intensity ALAN can disturb BP control and augment insulin resistance in SHR, and may represent a serious risk factor for cardiometabolic diseases. |
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Address |
Faculty of Natural Sciences, Comenius University, Animal Physiology and Ethology , Ilkovicova 6 , Slovakia , Bratislava, Slovakia, Slovakia , 84215 ; mzeman@fns.uniba.sk |
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English |
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ISSN |
0008-4212 |
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Notes |
PMID:31251886 |
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no |
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Call Number |
GFZ @ kyba @ |
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2567 |
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