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Author (up) Maggio, R.; Vaglini, F.; Rossi, M.; Fasciani, I.; Pietrantoni, I.; Marampon, F.; Corsini, G.U.; Scarselli, M.; Millan, M.J. url  doi
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  Title Parkinson's disease and light: The bright and the Dark sides Type Journal Article
  Year 2019 Publication Brain Research Bulletin Abbreviated Journal Brain Res Bull  
  Volume 150 Issue Pages 290-296  
  Keywords Humah Health; Light pollution; Near-infrared light; Parkinson's disease  
  Abstract Light exerts a major influence on human behaviour and health, mainly owing to the importance of sight in our lives, but also due to its entrainment of daily rhythms via the suprachiasmatic nucleus, the master pacemaker. Light may also be a useful clinical medium, as in lumino-therapy for the improvement of depressed mood. Further, as discussed herein, local application of near infrared light to the substantia nigra exerts neuroprotective properties in models of Parkinson's disease. However, light also has a darker side. In general, as regards the growing problem to human health – and the natural world – of excess exposure to artificial light: both urban glow and ubiquitous screens. Moreover, over-exposure to light, in particular fluorescent light, disrupts circadian rhythms and sleep, and may damage dopaminergic neurons. Is it, then, a neglected risk factor for Parkinson's disease? The present article discusses epidemiological and experimental evidence supporting beneficial and potentially deleterious impact of light on dopaminergic neurons and highlights the mechanisms whereby light might influence neuronal tissue.  
  Address Centre for Innovation in Neuropsychiatry, Institut de Recherches Servier, 125, Chemin de Ronde, 78290, Croissy sur Seine, France. Electronic address: mark.millan@servier.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0361-9230 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31226407 Approved no  
  Call Number GFZ @ kyba @ Serial 2586  
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