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Author (up) Nehme, P.A.; Amaral, F.; Lowden, A.; Skene, D.J.; Cipolla-Neto, J.; Moreno, C.R.C.
Title Reduced melatonin synthesis in pregnant night workers: metabolic implications for offspring Type Journal Article
Year 2019 Publication Medical Hypotheses Abbreviated Journal Medical Hypotheses
Volume 132 Issue Pages 109353
Keywords Human Health; Pregnancy; Melatonin; Melatonin synthesis; Circadian disruption; shift work
Abstract Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring. It is therefore postulated that female night workers when pregnant may expose the offspring to unwanted health threats. This may be explained by the fact that melatonin is essential for regulating energy metabolism and can influence reproductive activity. Moreover, the circadian misalignment caused by shift work affects fertility and the fetus, increasing the risk of miscarriage, premature birth and low birth weight, phenomena observed in night workers. Thus, we hypothesize that light-induced melatonin suppression as a result of night work may alter intrauterine metabolic programming in pregnant women, potentially leading to metabolic disorders in their offspring.
Address School of Public Health, University of São Paulo, Brazil
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0306-9877 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2610
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