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Author Dong, K.; Goyarts, E.C.; Pelle, E.; Trivero, J.; Pernodet, N. url  doi
openurl 
  Title Blue Light disrupts the circadian rhythm and create damage in skin cells Type Journal Article
  Year 2019 Publication International Journal of Cosmetic Science Abbreviated Journal Int J Cosmet Sci  
  Volume 41 Issue 6 Pages 558-562  
  Keywords Human Health; Circadian disruption; Skin; Clock genes  
  Abstract On a daily basis, the skin is exposed to many environmental stressors and insults. Over a 24-hr natural cycle, during the day, the skin is focused on protection; while at night, the skin is focused on repairing damage that occurred during daytime and getting ready for the next morning. Circadian rhythm provides the precise timing mechanism for engaging those different pathways necessary to keep a healthy skin through clock genes that are present in all skin cells. The strongest clue for determining cellular functions timing is through sensing light or absence of light (darkness). Here, we asked the question if blue light could be a direct entrainment signal to skin cells and also disrupt their circadian rhythm at night. Through a reporter assay for per1 transcription, we demonstrate that blue light at 410nm decreases per1 transcription in keratinocytes, showing that epidermal skin cells can sense light directly and control their own clock gene expression. This triggers cells to “think” it is daytime even at nighttime. Elsewhere, we measured different skin cell damage due to blue light exposure (at different doses and times of exposure) versus cells that were kept in full darkness. We show an increase of ROS production, DNA damage and inflammatory mediators. These deleterious effects can potentially increase overall skin damage over time and ultimately accelerates aging.  
  Address Materials Science & Engineering, Stony Brook University, Stony Brook  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title (up) Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0142-5463 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31418890 Approved no  
  Call Number GFZ @ kyba @ Serial 2618  
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