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Author (up) Nicholls, S. K., Casiraghi, L. P., Wang. W., Weber, E. T., & Harrington, M. E. url  openurl
  Title Evidence for Internal Desynchrony Caused by Circadian Clock Resetting Type Journal Article
  Year 2019 Publication Yale Journal of Biology and Medicine Abbreviated Journal  
  Volume 92 Issue 2 Pages 259-270  
  Keywords Review; Animals; Human Health  
  Abstract Circadian disruption has been linked to markers for poor health outcomes in humans and animal models. What is it about circadian disruption that is problematic? One hypothesis is that phase resetting of the circadian system, which occurs in response to changes in environmental timing cues, leads to internal desynchrony within the organism. Internal desynchrony is understood as acute changes in phase relationships between biological rhythms from different cell groups, tissues, or organs within the body. Do we have strong evidence for internal desynchrony associated with or caused by circadian clock resetting? Here we review the literature, highlighting several key studies from measures of gene expression in laboratory rodents. We conclude that current evidence offers strong support for the premise that some protocols for light-induced resetting are associated with internal desynchrony. It is important to continue research to test whether internal desynchrony is necessary and/or sufficient for negative health impact of circadian disruption.  
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  Call Number IDA @ intern @ Serial 2631  
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