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Author (up) Haraguchi, S.; Kamata, M.; Tokita, T.; Tashiro, K.-I.; Sato, M.; Nozaki, M.; Okamoto-Katsuyama, M.; Shimizu, I.; Han, G.; Chowdhury, V.S.; Lei, X.-F.; Miyazaki, T.; Kim-Kaneyama, J.-R.; Nakamachi, T.; Matsuda, K.; Ohtaki, H.; Tokumoto, T.; Tachibana, T.; Miyazaki, A.; Tsutsui, K. url  doi
  Title Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms Type Journal Article
  Year 2019 Publication ELife Abbreviated Journal Elife  
  Volume 8 Issue Pages e45306  
  Keywords Animals; chicken; neuroscience; Circadian disruption; pineal allopregnanolone; cell death  
  Abstract The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks.  
  Address Department of Biology, Waseda University, Tokyo, Japan; shogo.haraguchi(at)  
  Corporate Author Thesis  
  Publisher eLife Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2050-084X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31566568 Approved no  
  Call Number GFZ @ kyba @ Serial 2694  
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