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Author Hong, Y.; Lee, S.; Choi, J.; Jin, Y.; Won, J.; Hong, Y. url  doi
  Title Conditional Controlled Light/Dark Cycle Influences Exercise-Induced Benefits in a Rat Model with Osteoarthritis: In Vitro and In Vivo Study Type Journal Article
  Year 2019 Publication Journal of Clinical Medicine Abbreviated Journal J Clin Med  
  Volume 8 Issue 11 Pages 1855  
  Keywords Animals; environmental lighting; inflammation; musculoskeletal homeostasis; physical exercise  
  Abstract Physical exercise has long been recommended as a treatment for osteoarthritis (OA), though its effects vary based on the exercise protocol. Here, we examined whether environmental lighting conditions influence the anti-inflammatory benefits of exercise in a rat model of OA. Moderate-intensity treadmill exercise (Ex) was performed for six weeks under a 12:12 h light/dark (L/D) cycle, and compared against rats housed in a 24 h continuous light (L/L) environment. L/L conditions were associated with serological changes shortly after OA induction, which exacerbated the inflammatory microenvironment in the joint. Differentiation capacity was also impaired in bone precursor cells isolated from normal rats maintained under L/L conditions, despite elevated inflammatory responses. Exercise training under L/L conditions led to increased corticosterone levels in the blood, which exacerbated the progression of cartilaginous and synovial lesions. Osteoporotic phenomena were also observed in exercise-trained rats maintained under L/L conditions, along with inflammation-induced catabolism in the gastrocnemius muscle. Aberrant light/dark cycle conditions were also found to be associated with suppression of splenic Cry1 expression in exercise-trained rats, leading to dysregulation of immune responses. Taken together, these data suggest that lighting condition may be an important environmental factor influencing the exercise-induced benefits on OA.  
  Address Department of Medicine, Division of Hematology/Oncology, Harvard Medical SchoolBeth Israel, Deaconess Medical Center, Boston, MA 02215, USA.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition (up)  
  ISSN 2077-0383 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31684092 Approved no  
  Call Number GFZ @ kyba @ Serial 2729  
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