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Author (up) Mouland, J.W.; Martial, F.; Watson, A.; Lucas, R.J.; Brown, T.M. url  doi
  Title Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight Type Journal Article
  Year 2019 Publication Current Biology Abbreviated Journal Current Biology  
  Volume 29 Issue 24 Pages 4260-4267.e4  
  Keywords Animals; Circadian Rhythm; mouse models; cones  
  Abstract In humans, short-wavelength light evokes larger circadian responses than longer wavelengths. This reflects the fact that melanopsin, a key contributor to circadian assessments of light intensity, most efficiently captures photons around 480 nm and gives rise to the popular view that ‘‘blue’’ light exerts the strongest effects on the clock. However, in the natural world, there is often no direct correlation be- tween perceived color (as reported by the cone-based visual system) and melanopsin excitation. Accordingly, although the mammalian clock does receive cone-based chromatic signals, the influence of color on circadian responses to light remains unclear. Here, we define the nature and functional significance of chromatic influences on the mouse circadian sys- tem. Using polychromatic lighting and mice with altered cone spectral sensitivity (Opn1mwR), we generate conditions that differ in color (i.e., ratio of L- to S-cone opsin activation) while providing identical melanopsin and rod activation. When biased toward S-opsin activation (appearing ‘‘blue’’), these stimuli reliably produce weaker circadian behavioral responses than those favoring L-opsin (‘‘yellow’’). This influence of color (which is absent in animals lacking cone phototransduction; Cnga3/) aligns with natural changes in spectral composition over twilight, where decreasing solar angle is accompanied by a strong blue shift. Accordingly, we find that naturalistic color changes support circadian alignment when environmental conditions render diurnal variations in light intensity weak/ambiguous sources of timing information. Our data thus establish how color contributes to circadian entrainment in mammals and provide important new insight to inform the design of lighting environments that benefit health.  
  Address Centre for Biological Timing, Faculty of Biology, Medicine & Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK; timothy.brown(at)  
  Corporate Author Thesis  
  Publisher Cell Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0960-9822 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 2785  
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