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Author (up) Fasciani, I.; Petragnano, F.; Aloisi, G.; Marampon, F.; Rossi, M.; Francesca Coppolino, M.; Rossi, R.; Longoni, B.; Scarselli, M.; Maggio, R. url  doi
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  Title A new threat to dopamine neurons: the downside of artificial light Type Journal Article
  Year 2020 Publication Neuroscience Abbreviated Journal Neuroscience  
  Volume in press Issue Pages in press  
  Keywords Review; Human Health; Parkinson's disease; artificial light; dopamine neurons; melatonin; opsins; photoactivation  
  Abstract Growing awareness of adverse impacts of artificial light on human health has led to recognize light pollution as a significant global environmental issue. Despite, a large number of studies in rodent and monkey models of Parkinson's disease have reported that near infrared light has neuroprotective effects on dopaminergic neurons, recent findings have shown that prolonged exposure of rodents and birds to fluorescent artificial light results in an increase of neuromelanin granules in substantia nigra and loss of dopaminergic neurons. The observed detrimental effect seems to be dependent on a direct effect of light on the substantia nigra rather than a secondary effect of the alterations of circadian rhythms. Moreover, inferences from animal models to human studies have shown a positive correlation between the prevalence of Parkinson's disease and light pollution. The present article discusses experimental evidence supporting a potentially deleterious impact of light on dopaminergic neurons and highlights the mechanisms whereby light might damage neuronal tissue. Moreover, it analyses epidemiological evidence that suggests light pollution to be an environmental risk factor for Parkinson's disease.  
  Address Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: roberto.maggio@univaq.it  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0306-4522 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32142863 Approved no  
  Call Number GFZ @ kyba @ Serial 2839  
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