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Author (up) Niklaus, S.; Albertini, S.; Schnitzer, T.K.; Denk, N. url  doi
openurl 
  Title Challenging a Myth and Misconception: Red-Light Vision in Rats Type Journal Article
  Year 2020 Publication Animals : an Open Access Journal From MDPI Abbreviated Journal Animals (Basel)  
  Volume 10 Issue 3 Pages  
  Keywords animals; cones; electroretinogram; husbandry; photoreceptors; rat; red light; retina; rods  
  Abstract Due to the lack of L-cones in the rodent retina, it is generally assumed that red light is invisible to rodents. Thus, red lights and red filter foils are widely used in rodent husbandry and experimentation allowing researchers to observe animals in an environment that is thought to appear dark to the animals. To better understand red-light vision in rodents, we assessed retinal sensitivity of pigmented and albino rats to far-red light by electroretinogram. We examined the sensitivity to red light not only on the light- but also dark-adapted retina, as red observation lights in husbandry are used during the dark phase of the light cycle. Intriguingly, both rods and cones of pigmented as well as albino rats show a retinal response to red light, with a high sensitivity of the dark-adapted retina and large electroretinogram responses in the mesopic range. Our results challenge the misconception of rodents being red-light blind. Researchers and housing facilities should rethink the use of red observation lights at night.  
  Address Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, 4070 Basel, Switzerland  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2076-2615 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32138167 Approved no  
  Call Number GFZ @ kyba @ Serial 2844  
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