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Author (up) Reiter, R.J.; Tan, D.X.; Erren, T.C.; Fuentes-Broto, L.; Paredes, S.D. url  doi
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  Title Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis Type Journal Article
  Year 2009 Publication Integrative Cancer Therapies Abbreviated Journal Integr Cancer Ther  
  Volume 8 Issue 4 Pages 354-360  
  Keywords *Circadian Rhythm; Humans; Light/*adverse effects; Melatonin/antagonists & inhibitors; Neoplasms/*etiology/physiopathology; Risk Factors; Sleep Deprivation/complications; oncogenesis  
  Abstract In industrialized countries, certain types of cancer, most notably, breast and prostate, are more frequent than in poorly developed nations. This high cancer frequency is not explained by any of the conventional causes. Within the past decade, numerous reports have appeared that link light at night with an elevated cancer risk. The three major consequences of light at night are sleep deprivation, chronodisruption, and melatonin suppression. Each of these individually or in combination may contribute to the reported rise in certain types of cancer. In this article, the potential mechanisms underlying the basis of the elevated cancer risk are briefly discussed. Finally, if cancer is a consequence of excessive nighttime light, it is likely that other diseases/conditions may also be exaggerated by the widespread use of light after darkness onset.  
  Address Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA. reiter@uthscsa.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1534-7354 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20042411 Approved no  
  Call Number IDA @ john @ Serial 290  
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