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Author Maroni, M.J.; Capri, K.M.; Arruda, N.L.; Gelineau, R.R.; Deane, H.V.; Concepcion, H.A.; DeCourcey, H.; Monteiro De Pina, I.K.; Cushman, A.V.; Chasse, M.H.; Logan, R.W.; Seggio, J.A. url  doi
  Title Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet Type (up) Journal Article
  Year 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages  
  Keywords Animals; Mouse; circadian; high-fat diet; locomotor activity; photoperiod; strain differences  
  Abstract Altered circadian rhythms have negative consequences on health and behavior. Emerging evidence suggests genetics influences the physiological and behavioral responses to circadian disruption. We investigated the effects of a 21 h day (T = 21 cycle), with high-fat diet consumption, on locomotor activity, explorative behaviors, and health in male C57BL/6J and C57BL/6N mice. Mice were exposed to either a T = 24 or T = 21 cycle and given standard rodent chow (RC) or a 60% high-fat diet (HFD) followed by behavioral assays and physiological measures. We uncovered numerous strain differences within the behavioral and physiological assays, mainly that C57BL/6J mice exhibit reduced susceptibility to the obesogenic effects of (HFD) and anxiety-like behavior as well as increased circadian and novelty-induced locomotor activity compared to C57BL/6N mice. There were also substrain-specific differences in behavioral responses to the T = 21 cycle, including exploratory behaviors and circadian locomotor activity. Under the 21-h day, mice consuming RC displayed entrainment, while mice exposed to HFD exhibited a lengthening of activity rhythms. In the open-field and light-dark box, mice exposed to the T = 21 cycle had increased novelty-induced locomotor activity with no further effects of diet, suggesting daylength may affect mood-related behaviors. These results indicate that different circadian cycles impact metabolic and behavioral responses depending on genetic background, and despite circadian entrainment.  
  Address Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32400203 Approved no  
  Call Number GFZ @ kyba @ Serial 2919  
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