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Author (up) LeGates, T.A.; Fernandez, D.C.; Hattar, S. url  doi
  Title Light as a central modulator of circadian rhythms, sleep and affect Type Journal Article
  Year 2014 Publication Nature Reviews. Neuroscience Abbreviated Journal Nat Rev Neurosci  
  Volume 15 Issue 7 Pages 443-454  
  Keywords Human Health; photobiology; circadian disruption; asynchronization; sleep; mood; Review  
  Abstract Light has profoundly influenced the evolution of life on earth. As widely appreciated, light enables us to generate images of our environment. However, light – through intrinsically photosensitive retinal ganglion cells (ipRGCs) – also influences behaviours that are essential for our health and quality of life but are independent of image formation. These include the synchronization of the circadian clock to the solar day, tracking of seasonal changes and the regulation of sleep. Irregular light environments lead to problems in circadian rhythms and sleep, which eventually cause mood and learning deficits. Recently, it was found that irregular light can also directly affect mood and learning without producing major disruptions in circadian rhythms and sleep. In this Review, we discuss the indirect and direct influence of light on mood and learning, and provide a model for how light, the circadian clock and sleep interact to influence mood and cognitive functions.  
  Address 1] Johns Hopkins University, Department of Biology, Baltimore, Maryland 21218, USA. [2] Johns Hopkins University, Department of Neuroscience, Baltimore, Maryland 21218, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1471-003X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24917305 Approved no  
  Call Number IDA @ john @ Serial 299  
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