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Author (up) Pauers, M.J.; Kuchenbecker, J.A.; Neitz, M.; Neitz, J. url  doi
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  Title Changes in the colour of light cue circadian activity Type Journal Article
  Year 2012 Publication Animal Behaviour Abbreviated Journal Anim Behav  
  Volume 83 Issue 5 Pages 1143-1151  
  Keywords melanopsin; Circadian Rhythm; physiology of vision; biology  
  Abstract The discovery of melanopsin, the non-visual opsin present in intrinsically photosensitive retinal ganglion cells (ipRGCs), has created great excitement in the field of circadian biology. Now, researchers have emphasized melanopsin as the main photopigment governing circadian activity in vertebrates. Circadian biologists have tested this idea under standard laboratory, 12h Light: 12h Dark, lighting conditions that lack the dramatic daily colour changes of natural skylight. Here we used a stimulus paradigm in which the colour of the illumination changed throughout the day, thus mimicking natural skylight, but luminance, sensed intrinsically by melanopsin containing ganglion cells, was kept constant. We show in two species of cichlid, Aequidens pulcher and Labeotropheus fuelleborni, that changes in light colour, not intensity, are the primary determinants of natural circadian activity. Moreover, opponent-cone photoreceptor inputs to ipRGCs mediate the sensation of wavelength change, and not the intrinsic photopigment, melanopsin. These results have implications for understanding the evolutionary biology of non-visual photosensory pathways and answer long-standing questions about the nature and distribution of photopigments in organisms, including providing a solution to the mystery of why nocturnal animals routinely have mutations that interrupt the function of their short wavelength sensitive photopigment gene.  
  Address Department of Ophthalmology, University of Washington Medical School, 1959 NE Pacific Street, Seattle, Washington, 98195, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0003-3472 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22639465; PMCID:PMC3358782 Approved no  
  Call Number IDA @ john @ Serial 30  
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