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Author (up) Rumanova, V.S.; Okuliarova, M.; Zeman, M. url  doi
  Title Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior Type Journal Article
  Year 2020 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 21 Issue 15 Pages  
  Keywords Review; Animals; behavior; chronodisruption; circadian; corticosterone; dim light at night; hormones; locomotor activity; melatonin; metabolism; rhythms  
  Abstract The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. The light:dark cycle is the most reliable environmental agent, which entrains circadian rhythms, although its credibility has decreased because of the extensive use of artificial light at night. Light pollution can compromise performance and health, but underlying mechanisms are not fully understood. The present review assesses the consequences induced by constant light (LL) in comparison with dim light at night (dLAN) on the circadian control of metabolism and behavior in rodents, since such an approach can identify the key mechanisms of chronodisruption. Data suggest that the effects of LL are more pronounced compared to dLAN and are directly related to the light level and duration of exposure. Dim LAN reduces nocturnal melatonin levels, similarly to LL, but the consequences on the rhythms of corticosterone and behavioral traits are not uniform and an improved quantification of the disrupted rhythms is needed. Metabolism is under strong circadian control and its disruption can lead to various pathologies. Moreover, metabolism is not only an output, but some metabolites and peripheral signal molecules can feedback on the circadian clockwork and either stabilize or amplify its desynchronization.  
  Address Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1422-0067 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32751870 Approved no  
  Call Number GFZ @ kyba @ Serial 3062  
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