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Author (up) Fleury, G.; Masis-Vargas, A.; Kalsbeek, A. url  doi
  Title Metabolic Implications of Exposure to Light at Night: Lessons from Animal and Human Studies Type Journal Article
  Year 2020 Publication Obesity (Silver Spring, Md.) Abbreviated Journal Obesity (Silver Spring)  
  Volume 28 Suppl 1 Issue Pages S18-S28  
  Keywords Review; Human Health; Animals; Obesity  
  Abstract Lately, the incidence of overweight, obesity, and type 2 diabetes has shown a staggering increase. To prevent and treat these conditions, one must look at their etiology. As life on earth has evolved under the conditions of nature's 24-hour light/dark cycle, it seems likely that exposure to artificial light at night (LAN) would affect physiology. Indeed, ample evidence has shown that LAN impacts many metabolic parameters, at least partly via the biological clock in the suprachiasmatic nucleus of the hypothalamus. This review focuses on the impact of chronic and acute effects of LAN of different wavelengths on locomotor activity, food intake, the sleep/wake cycle, body temperature, melatonin, glucocorticoids, and glucose and lipid metabolism. While chronic LAN disturbs daily rhythms in these parameters, experiments using short-term LAN exposure also have shown acute negative effects in metabolically active peripheral tissues. Experiments using LAN of different wavelengths not only have indicated an important role for melanopsin, the photopigment found in intrinsically photosensitive retinal ganglion cells, but also provided evidence that each wavelength may have a specific impact on energy metabolism. Importantly, exposure to LAN has been shown to impact glucose homeostasis also in humans and to be associated with an increased incidence of overweight, obesity, and atherosclerosis.  
  Address Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience (NIN), Amsterdam, the Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1930-7381 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32700826 Approved no  
  Call Number GFZ @ kyba @ Serial 3079  
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