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Author (up) Olde Engberink, A.H.O.; Huisman, J.; Michel, S.; Meijer, J.H. url  doi
  Title Brief light exposure at dawn and dusk can encode day-length in the neuronal network of the mammalian circadian pacemaker Type Journal Article
  Year 2020 Publication FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology Abbreviated Journal Faseb J  
  Volume in press Issue Pages in press  
  Keywords Animals; Gaba; plasticity; seasonal; suprachiasmatic nucleus  
  Abstract The central circadian pacemaker in mammals, the suprachiasmatic nucleus (SCN), is important for daily as well as seasonal rhythms. The SCN encodes seasonal changes in day length by adjusting phase distribution among oscillating neurons thereby shaping the output signal used for adaptation of physiology and behavior. It is well-established that brief light exposure at the beginning and end of the day, also referred to as “skeleton” light pulses, are sufficient to evoke the seasonal behavioral phenotype. However, the effect of skeleton light exposure on SCN network reorganization remains unknown. Therefore, we exposed mice to brief morning and evening light pulses that mark the time of dawn and dusk in a short winter- or a long summer day. Single-cell PER2::LUC recordings, electrophysiological recordings of SCN activity, and measurements of GABA response polarity revealed that skeleton light-regimes affected the SCN network to the same degree as full photoperiod. These results indicate the powerful, yet potentially harmful effects of even relatively short light exposures during the evening or night for nocturnal animals.  
  Address Department of Cellular and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, the Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0892-6638 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32869393 Approved no  
  Call Number GFZ @ kyba @ Serial 3116  
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