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Author (up) Fonken, L.K.; Nelson, R.J. url  doi
  Title The Effects of Light at Night on Circadian Clocks and Metabolism Type Book Chapter
  Year 2014 Publication Endocrine Reviews Abbreviated Journal Endocr Rev  
  Volume 35 Issue 4 Pages 648-670  
  Keywords Human Health; Circadian Rhythm; clock genes; epidemiology; light at night; review  
  Abstract Most organisms display endogenously produced approximately ~24 h fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body, with the suprachiasmatic nucleus of the hypothalamus serving as the master circadian oscillator at the top of the hierarchy. Appropriate circadian regulation is important for many homeostatic functions including energy regulation. Multiple genes involved in nutrient metabolism display rhythmic oscillations and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion. Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption. Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans. Importantly, circadian rhythms are most potently synchronized to the external environment by light information and exposure to light at night potentially disrupts circadian system function. Since the advent of electric lights around the turn of the 20th century, exposure to artificial and irregular light schedules has become commonplace. The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders. In this review, we propose that exposure to light at night alters metabolic function through disruption of the circadian system. We first provide an introduction to the circadian system, with a specific emphasis on the effects of light on circadian rhythms. Next we address interactions between the circadian system and metabolism. Finally, we review current experimental and epidemiological work directly associating exposure to light at night and metabolism.  
  Address Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210 USA  
  Corporate Author Thesis  
  Publisher Endocrine Society Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24673196 Approved no  
  Call Number IDA @ john @ Serial 314  
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