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Author (up) Landgraf, D.; McCarthy, M.J.; Welsh, D.K. url  doi
openurl 
  Title The role of the circadian clock in animal models of mood disorders Type Journal Article
  Year 2014 Publication Behavioral Neuroscience Abbreviated Journal Behav Neurosci  
  Volume 128 Issue 3 Pages 344-359  
  Keywords *Circadian Rhythm; mood; mood disorders; circadian disruption  
  Abstract An association between circadian clock function and mood regulation is well established and has been proposed as a factor in the development of mood disorders. Patients with depression or mania suffer disturbed sleep-wake cycles and altered rhythms in daily activities. Environmentally disrupted circadian rhythms increase the risk of mood disorders in the general population. However, proof that a disturbance of circadian rhythms is causally involved in the development of psychiatric disorders remains elusive. Using clock gene mutants, manipulations of sleep-wake and light-dark cycles, and brain lesions affecting clock function, animal models have been developed to investigate whether circadian rhythm disruptions alter mood. In this review, selected animal models are examined to address the issue of causality between circadian rhythms and affective behavior.  
  Address Research Service, Veterans Affairs San Diego Healthcare System  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0735-7044 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24660657 Approved no  
  Call Number IDA @ john @ Serial 316  
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