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Author (up) Adeniyi, M.J.; Agoreyo, F.O.; Olorunnisola, O.L.; Olaniyan, O.T.; Seriki, S.A.; Ozolua, P.O.; Odetola, A.A. url  doi
  Title Photo-pollution disrupts reproductive homeostasis in female rats: The duration-dependent role of selenium administrations Type Journal Article
  Year 2020 Publication The Chinese Journal of Physiology Abbreviated Journal Chin J Physiol  
  Volume 63 Issue 5 Pages 235-243  
  Keywords Animals; Estrous cycle ratio; follicle-stimulating hormone; luteinizing hormone; photo-pollution; reproductive homeostasis; selenium  
  Abstract Although selenium is known to be essential for reproductive function, studies have indicated the adverse effect with its prolonged use. The present study investigated the duration-related effect of selenium administrations on reproductive hormones and estrous cycle indices in adult female Wistar rats exposed to a model of light pollution using altered photoperiod (AP). Ninety-six cyclic female Wistar rats displaying 4-5 days' estrous cycle length (ECL) and weighing 148-152 g were randomly divided into short and long experimental cohorts consisting of six groups each and spanning for 1 and 8 weeks, respectively. Each consisted of control, high selenium dose (HSE), low selenium dose (LSE), AP, AP + HSE, and AP + LSE. The rats were orally administered high dose (150 mug/kg) and low dose (100 mug/kg) of sodium selenite once per day. The estrous cycle indices were monitored. Plasma levels of follicle-stimulating hormone, luteinizing hormone (LH), estradiol (E), progesterone (P), prolactin, E/P ratio, and histology of ovary and uterine horn were evaluated. The statistical analysis was performed using Statistical Package for the Social Sciences. In AP rats, HSE and LSE caused no significant effect on LH, E, P, and E/P ratio, ECL, estrus interval (EI), and estrous cycle ratio (ECR). The effect of HSE and LSE on LH, E, P, E/P ratio, and ECL showed no duration-dependent increase, but there was a duration-dependent increase in EI and ECR at low dose. The study indicated that administration of HSE of selenium improved reproductive function in photo-pollution-exposed rats irrespective of the duration of treatment.  
  Address Department of Anatomy, Edo University Iyamho, Edo State, Nigeria  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0304-4920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:33109790 Approved no  
  Call Number GFZ @ kyba @ Serial 3190  
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