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Author (up) Harrison, E.M.; Gorman, M.R. url  doi
openurl 
  Title Changing the waveform of circadian rhythms: considerations for shift-work Type Journal Article
  Year 2012 Publication Frontiers in Neurology Abbreviated Journal Front Neurol  
  Volume 3 Issue Pages 72  
  Keywords Editorial; dysrhythmia; night shift; shift-work; split schedules; waveform  
  Abstract Circadian disruption in shift-work is common and has deleterious effects on health and performance. Current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker, which unfortunately in humans, shifts slowly and often incompletely. Temporal reorganization of rhythmic waveform (i.e., the shape of its 24 h oscillation), rather than phase, however, may better match performance demands of shift-workers and can be quickly and feasibly implemented in animals. In fact, a bifurcated pacemaker waveform may permit stable entrainment of a bimodal sleep/wake rhythm promoting alertness in both night and daylight hours. Although bifurcation has yet to be formally assessed in humans, evidence of conserved properties of circadian organization and plasticity predict its occurrence: humans respond to conventional manipulations of waveform (e.g., photoperiodism); behaviorally, the sleep/wake rhythm is adaptable; and finally, the human circadian system likely derives from the same multiple cellular oscillators that permit waveform flexibility in the rodent pacemaker. In short, investigation into untried manipulations of waveform in humans to facilitate adjustment to challenging schedules is justified.  
  Address Department of Psychology, Center for Chronobiology, University of California San Diego La Jolla, CA, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1664-2295 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22557994; PMCID:PMC3340571 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 460  
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