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Author (up) Reiter, R.J.; Tan, D.-X.; Korkmaz, A.; Ma, S. url  doi
  Title Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression Type Journal Article
  Year 2012 Publication Annals of Medicine Abbreviated Journal Ann Med  
  Volume 44 Issue 6 Pages 564-577  
  Keywords Human Health; Adolescent; Adult; Animals; Child; Chronobiology Disorders/*epidemiology; Comorbidity; Disease Models, Animal; Humans; Light/adverse effects; Melatonin/*deficiency/physiology; Metabolic Syndrome X/*epidemiology; Mice; Obesity/*epidemiology; Rats; Sleep Deprivation/*epidemiology  
  Abstract Obesity has become an epidemic in industrialized and developing countries. In 30 years, unless serious changes are made, a majority of adults and many children will be classified as overweight or obese. Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. If the current trend continues as predicted, health care systems may be incapable of handling the myriad of obesity-related diseases. The financial costs, including those due to medical procedures, absenteeism from work, and reduced economic productivity, will jeopardize the financial well-being of industries. The current review summarizes the potential contributions of three processes that may be contributing to humans becoming progressively more overweight: circadian or chronodisruption, sleep deficiency, and melatonin suppression. Based on the information provided in this survey, life-style factors (independent of the availability of abundant calorie-rich foods) may aggravate weight gain. Both epidemiological and experimental data support associations between disrupted physiological rhythms, a reduction in adequate sleep, and light-at-night-induced suppression of an essential endogenously produced molecule, melatonin. The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled.  
  Address Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0785-3890 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21668294 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 523  
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