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Author (up) Salgado-Delgado, R.; Tapia Osorio, A.; Saderi, N.; Escobar, C. url  doi
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  Title Disruption of circadian rhythms: a crucial factor in the etiology of depression Type Journal Article
  Year 2011 Publication Depression Research and Treatment Abbreviated Journal Depress Res Treat  
  Volume 2011 Issue Pages 839743  
  Keywords Human Health  
  Abstract Circadian factors might play a crucial role in the etiology of depression. It has been demonstrated that the disruption of circadian rhythms by lighting conditions and lifestyle predisposes individuals to a wide range of mood disorders, including impulsivity, mania and depression. Also, associated with depression, there is the impairment of circadian rhythmicity of behavioral, endocrine, and metabolic functions. Inspite of this close relationship between both processes, the complex relationship between the biological clock and the incidence of depressive symptoms is far from being understood. The efficiency and the timing of treatments based on chronotherapy (e.g., light treatment, sleep deprivation, and scheduled medication) indicate that the circadian system is an essential target in the therapy of depression. The aim of the present review is to analyze the biological and clinical data that link depression with the disruption of circadian rhythms, emphasizing the contribution of circadian desynchrony. Therefore, we examine the conditions that may lead to circadian disruption of physiology and behavior as described in depressive states, and, according to this approach, we discuss therapeutic strategies aimed at treating the circadian system and depression.  
  Address Departamento de Biologia Celular y Fisiologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 04306 Mexico, DF, Mexico  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2090-1321 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21845223; PMCID:PMC3154570 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 524  
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