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Author Kloog, I.; Haim, A.; Stevens, R.G.; Barchana, M.; Portnov, B.A. url  doi
  Title Light at night co-distributes with incident breast but not lung cancer in the female population of Israel Type Journal Article
  Year 2008 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume 25 Issue 1 Pages 65-81  
  Keywords Human Health; Breast Neoplasms/*epidemiology/etiology; Female; Humans; Israel/epidemiology; *Light; Lung Neoplasms/epidemiology; Multivariate Analysis; Risk Factors  
  Abstract Recent studies of shift-working women have reported that excessive exposure to light at night (LAN) may be a risk factor for breast cancer. However, no studies have yet attempted to examine the co-distribution of LAN and breast cancer incidence on a population level with the goal to assess the coherence of these earlier findings with population trends. Coherence is one of Hill's “criteria” (actually, viewpoints) for an inference of causality. Nighttime satellite images were used to estimate LAN levels in 147 communities in Israel. Multiple regression analysis was performed to investigate the association between LAN and breast cancer incidence rates and, as a test of the specificity of our method, lung cancer incidence rates in women across localities under the prediction of a link with breast cancer but not lung cancer. After adjusting for several variables available on a population level, such as ethnic makeup, birth rate, population density, and local income level, a strong positive association between LAN intensity and breast cancer rate was revealed (p<0.05), and this association strengthened (p<0.01) when only statistically significant factors were filtered out by stepwise regression analysis. Concurrently, no association was found between LAN intensity and lung cancer rate. These results provide coherence of the previously reported case-control and cohort studies with the co-distribution of LAN and breast cancer on a population basis. The analysis yielded an estimated 73% higher breast cancer incidence in the highest LAN exposed communities compared to the lowest LAN exposed communities.  
  Address Department of Natural Resources & Environmental Management, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18293150 Approved no  
  Call Number (up) LoNNe @ christopher.kyba @ Serial 528  
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