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Author (up) Erren, T.C.; Pape, H.G.; Reiter, R.J.; Piekarski, C. url  doi
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  Title Chronodisruption and cancer Type Journal Article
  Year 2008 Publication Die Naturwissenschaften Abbreviated Journal Naturwissenschaften  
  Volume 95 Issue 5 Pages 367-382  
  Keywords Human Health; Animals; Chronobiology Phenomena/*physiology; *Circadian Rhythm; Humans; Incidence; Light; Mammals; Neoplasms/*epidemiology; Work Schedule Tolerance  
  Abstract Research into health effects of chronodisruption (CD), a relevant disturbance of the circadian organization of physiology, endocrinology, metabolism and behaviour, is evolving at a rapid pace. With regard to malignancies, our synthesis of key experiments indicates that CD can play a causal role for cancer growth and tumor progression in animals. Moreover, our meta-analyses of 30 epidemiological studies evince that flight personnel and shift workers exposed to chronodisruption may have increased breast and prostate cancer risks: summary relative risks (RRs) for investigations of flight personnel and of shift workers suggested a 70 and 40% increase in the risk of breast cancer, respectively, and excess relative risks of prostate cancer in nine studies in flight personnel (40%) and in two studies in male shift workers. There was a remarkable indication of homogeneity of results from the individual studies that contribute to the average statistics. However, in view of doubts about whether the differing assessments of CD can really be regarded as valid reflections of the same causative phenomenon and the lack of control of covariates in the majority of studies, it is premature to conclude that the risk observations reflect a real, rather than spurious, association with CD. The challenge for future epidemiological investigations of the biologically plausible links between chronodisruption and human cancers is to conduct studies which appreciate details of transmeridian travelling, of shift work and of covariates for the development of the diseases.  
  Address School of Medicine and Dentistry, University of Cologne, Cologne, Germany. tim.erren@uni-koeln.de  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-1042 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18196215 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 744  
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