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Author (down) Fonken, L.K.; Finy, M.S.; Walton, J.C.; Weil, Z.M.; Workman, J.L.; Ross, J.; Nelson, R.J. url  doi
  Title Influence of light at night on murine anxiety- and depressive-like responses Type Journal Article
  Year 2009 Publication Behavioural Brain Research Abbreviated Journal Behav Brain Res  
  Volume 205 Issue 2 Pages 349-354  
  Keywords Human Health; Animals; Anxiety/*physiopathology; Corticosterone/blood; Depression/*physiopathology; Dietary Sucrose/administration & dosage; Drinking Behavior/physiology; Light/*adverse effects; Lighting; Locomotion/physiology; Male; Maze Learning; Mice; Neuropsychological Tests; Organ Size; Photic Stimulation; *Photoperiod; Random Allocation; Swimming; Testis/pathology  
  Abstract Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake cycle in animals. Other behavioural responses to LL have been reported, but are inconsistent. The present experiment sought to determine whether LL produces changes in affective responses and whether behavioural changes are mediated by alterations in glucocorticoid concentrations. Relative to conspecifics maintained in a light/dark cycle (LD, 16:8 light/dark), male Swiss-Webster mice exposed to LL for three weeks increased depressive-like behavioural responses as evaluated by the forced swim test and sucrose anhedonia. Furthermore, providing a light escape tube reversed the effects of LL in the forced swim test. LL mice displayed reduced anxiety as evaluated by the open field and elevated-plus maze. Glucocorticoid concentrations were reduced in the LL group suggesting that the affective behavioural responses to LL are not the result of elevated corticosterone. Additionally, mice housed in LD with a clear tube displayed increased paired testes mass as compared to LL mice. Taken together, these data provide evidence that exposure to unnatural lighting can induce significant changes in affect, increasing depressive-like and decreasing anxiety-like responses.  
  Address Department of Psychology, The Ohio State University, Columbus, OH 43210, USA.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0166-4328 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19591880 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 749  
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