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Author (up) Haus, E.; Smolensky, M. url  doi
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  Title Biological clocks and shift work: circadian dysregulation and potential long-term effects Type Journal Article
  Year 2006 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 17 Issue 4 Pages 489-500  
  Keywords Human Health; Adaptation, Physiological; Animals; Biological Clocks; Cardiovascular Abnormalities/etiology; Chronobiology Disorders/*complications/physiopathology; Chronobiology Phenomena; Humans; Neoplasms/etiology; Occupational Diseases/*etiology; Risk Factors; Suprachiasmatic Nucleus/physiopathology; *Work Schedule Tolerance  
  Abstract Long-term epidemiologic studies on large numbers of night and rotating shift workers have suggested an increase in the incidence of breast and colon cancer in these populations. These studies suffer from poor definition and quantification of the work schedules of the exposed subjects. Against this background, the pathophysiology of phase shift and phase adaptation is reviewed. A phase shift as experienced in night and rotating shift work involves desynchronization at the molecular level in the circadian oscillators in the central nervous tissue and in most peripheral tissues of the body. There is a change in the coordination between oscillators with transient loss of control by the master-oscillator (the Suprachiasmatic Nucleus, SCN) in the hypothalamus. The implications of the pathophysiology of phase shift are discussed for long-term health effects and for the design of ergonomic work schedules minimizing the adverse health effects upon the worker.  
  Address Department of Laboratory Medicine & Pathology, University of Minnesota, Health Partners Medical Group, Regions Hospital, St. Paul, Minnesota 55101, USA. Erhard.X.Haus@Healthpartners.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16596302 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 760  
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