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Author (up) Kanikowska, D.; Sugenoya, J.; Sato, M.; Shimizu, Y.; Inukai, Y.; Nishimura, N.; Iwase, S. url  doi
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  Title Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone, metabolites of catecholamine and cortisol in healthy volunteers Type Journal Article
  Year 2009 Publication International Journal of Biometeorology Abbreviated Journal Int J Biometeorol  
  Volume 53 Issue 6 Pages 479-485  
  Keywords Human Health; Adrenocorticotropic Hormone/*blood; Catecholamines/*blood; Circadian Rhythm/*physiology; Humans; Hydrocortisone/*blood; Interleukin-6/*blood; Male; Reference Values; *Seasons; Young Adult  
  Abstract We investigated seasonal changes in blood concentrations of interleukin-6 (IL-6), adrenocorticotrophic hormone (ACTH), metabolites of catecholamine (VMA, HVA, and 5-HIAA) and cortisol in humans. Eight volunteers were investigated at four times during the year (February, May, August and October) at latitude 35 degrees N. The mean ambient temperature at the collection periods was higher in the order of summer > autumn approximately spring > winter. Changes in mood were also monitored by a profile of mood states (POMS) questionnaire. The concentration of IL-6 was significantly higher in winter and summer than in spring and autumn. The concentrations of ACTH, HVA and VMA were significantly higher in summer. No seasonal variation was detected in cortisol. There were significant differences among the seasons in subscale tension and anger in the POMS questionnaire; the tension subscale showed significant differences between spring and autumn, with a higher score in spring. The results demonstrate that Il-6, ACTH, HVA and VMA exhibit statistically significant seasonal rhythms, which might have important diagnostic and therapeutic implications.  
  Address Department of Physiology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan. dkanikowska@hotmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7128 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19506914 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 768  
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