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Author (up) Wilhelm, I.; Born, J.; Kudielka, B.M.; Schlotz, W.; Wust, S. url  doi
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  Title Is the cortisol awakening rise a response to awakening? Type Journal Article
  Year 2007 Publication Psychoneuroendocrinology Abbreviated Journal Psychoneuroendocrinology  
  Volume 32 Issue 4 Pages 358-366  
  Keywords Human Health; Adrenocorticotropic Hormone/blood; Adult; Arousal/*physiology; Circadian Rhythm; Humans; Hydrocortisone/blood/*metabolism; Hypothalamo-Hypophyseal System/physiology; Male; Pituitary-Adrenal System/physiology; Saliva/chemistry; Sleep/physiology  
  Abstract A distinct rise in cortisol levels that occurs after morning awakening is increasingly used as an indicator of adrenocortical activity which is associated with different pathologies. Although it was previously assumed that the transition from sleep to wake is essential for the occurrence of the cortisol morning rise, this has never been tested. Here, we examined 16 healthy young men (20-33 yrs) between 2300 and 0800 h under sleep laboratory conditions. Serum cortisol and plasma adrenocorticotropin (ACTH) as well as salivary cortisol levels (after subjects were woken up at 0700 h) were repeatedly assessed. In a supplementary study condition, salivary cortisol levels in the first hour after awakening were measured at the subjects' home on two consecutive days. Comparison of pre- and post awakening measurements revealed significantly steeper increases in cortisol and ACTH after awakening. The rise in cortisol upon awakening under laboratory conditions did not significantly differ from that observed at home. We conclude that the cortisol increase after awakening is a response to morning awakening that is distinct from the circadian rise in hypothalamo-pituitary-adrenal (HPA) activity in the morning hours. Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition.  
  Address Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0306-4530 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17408865 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 834  
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